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Permeability Of Hydrophilic
Beginning of essay
SUMMARY
Investigations of the integrity and transport characteristics of 2/4/A1 cells
have been done in this report. The cell line was isolated from rat fetal
intestinal epithelial cells and transfected with thermolabile SV40 large T
antigen.
These cells proliferated at 33 °C, but eliminated the a ....
Middle of essay ...., which contains the blood
and lymph vessels that then transport the absorbed drugs to other parts of the
body (Artursson 1991).
The cell monolayer is comprised of two parallel barriers: the cell membrane and
the tight junctions. Most drugs are absorbed by a passive diffusion across the
cell membrane by the transcellular route, or across the tight junctions between
the cells - the paracellular route. Drug transport can also be carrier mediated,
when the drug utilizes transporters located in the.... |
Number of words: 2422 |
Approximate pages: 9 |
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