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Excretion And Elimination Of Toxicants And Their Metabolites

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The first topic that was covered by this chapter was the excretion of wastes by the Renal system. The first step that occurs in the kidney deals with the nephron, which is the functional unit of the kidney. In the glomerulus the formation of urine begins with the passive filtration of plasma thro ....

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....d to excrete solutes. Secretion may be either passive or active. Secretions include organic bases, which occur in the pars recta of the proximal tubule. Secretions of weak bases and two weak acids occur passively. Other mechanisms involves the use of a mechanism that is called ion trapping. At a certain pH the compounds are more ionized. Outside of the tubule these compounds are non-ionized and are lipophilic. Thus they are able to diffuse across the membranes of the tubule. Once inside, the pH ....
Number of words: 1076 Approximate pages: 4

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